Table 1 Assay and method validation parameters for the determination of propranolol and methimazole by the proposed TLC method

Calibration range (µg/band)

0.04–1.0

0.1–1.0

0.06 −1.2

0.1–1.2

Slope

0.8072

4.3319

0.5653

4.5366

Intercept

0.1781

− 0.3221

0.1904

− 0.2376

Correlation coefficient

0.9998

0.9998

0.9997

0.9996

Accuracy

99.64

100.26

–

Robustness parameters (RSD %) ^a

- 33% NH₃ solution (0.05 ± 1%)

- Acetone (1 ± 1% mL)

- Saturation time (10 ± 5 min)

–

1.517

0. 698

1.982

1.479

1.257

1.730

LLOQ (µg/band)

0.06

0.1

ULOQ (µg/band)

1.2

1.2