Design, synthesis, biological assessments and computational studies of 3-substituted phenyl quinazolinone derivatives as promising anti-cancer agents

Table 6 In silico ADME of studied structures

Entry	Absorption		Distribution
Compounds	%HIA	In vitro Caco-2 cell permeability (nm s⁻¹)	In vitro skin permeability (LogKp, cm s⁻¹)	% In vitro plasma protein binding	%BBB
7a	95.27	11.93	− 3.37	91.12	1.04
7b	95.28	12.84	− 3.65	86.49	1.03
7c	95.83	6.51	− 3.25	90.69	1.68
7d	92.87	15.49	− 4.25	97.91	1.15
7e	93.98	10.23	− 4.10	95.12	1.99
7f	96.63	25.13	− 3.28	100	0.136
7g	95.79	27.15	− 2.46	95.95	7.45
7h	95.88	27.99	− 2.43	94.96	7.86
7i	95.08	17.99	− 3.36	87.52	0.76
7j	95.10	19.09	− 3.63	84.72	0.73
7k	95.67	16.72	− 3.38	89.30	1.06
7l	88.83	18.97	− 4.30	97.20	1.06
7m	96.50	25.99	− 3.23	96.67	0.08
7n	95.73	25.62	− 2.43	93.34	5.83
7o	95.85	26.22	− 2.51	96.09	6.37

ISSN: 2661-801X