Design, synthesis, biological assessments and computational studies of 3-substituted phenyl quinazolinone derivatives as promising anti-cancer agents

Table 5 Physicochemical properties of the studied ligands

Compounds	MW (g/mol)	LogP	HBD	HBA	TPSA (Å²)	n-RB	Lipinski violation
7a	321.16	3.47	2	3	72.94	2	0
7b	339.15	3.86	2	4	72.94	2	0
7c	355.61	3.98	2	3	72.94	2	0
7d	365.17	3.25	3	4	96.25	4	0
7e	399.62	3.75	3	4	96.25	4	0
7f	377.22	3.70	1	3	67.23	4	0
7g	411.28	5.12	2	2	58.95	4	0
7h	431.70	5.39	2	2	58.95	4	1
7i	331.17	3.35	2	3	72.94	2	0
7j	349.16	3.74	2	4	72.94	2	0
7k	365.61	3.86	2	3	72.94	2	0
7l	375.18	3.13	3	4	96.25	4	0
7m	387.23	3.59	1	3	67.23	4	0
7n	421.29	4.75	2	2	58.95	4	1
7o	441.71	5.01	2	2	58.95	4	1
Rule of Lipinski	≤ 500	≤ 5	≤ 5	≤ 10	≤ 140	≤ 10	≤ 1

ISSN: 2661-801X