BMC Chemistry

Table 2 Optimization of the model reaction using Fe₃O₄@SiO₂-SnCl₄ under reflux (I) and ultrasound irradiation (II) in water^a

From: Fe₃O₄@SiO₂-SnCl₄-promoted synthesis, cytotoxic evaluation, molecular docking, and MD simulation of some indenopyrido[2,3-d]pyrimidine derivatives

Entry	Method I (∆)			Method II (US)
	Catalyst/(g)			Catalyst/(g)
	Time (min)		Yield (%)^b	Time (min)		Yield (%)^b
1	none			none
1	120	35		20	40
2	Fe₃O₄@SiO₂/0.10			Fe₃O₄@SiO₂/0.10
2	30	55		10	60
3	nano-Fe₃O₄/0.10			nano-Fe₃O₄/0.10
3	30	70		10	75
4	SnCl₄·SiO₂/0.10			SnCl₄·SiO₂/0.10
4	50	60		12	70
5	Fe₃O₄@SiO₂-SnCl₄/0.005			Fe₃O₄@SiO₂-SnCl₄/0.005
5	45	75		7	80
6	Fe₃O₄@SiO₂-SnCl₄/0.010			Fe₃O₄@SiO₂-SnCl₄/0.010
6	40	85		4	90
7	Fe₃O₄@SiO₂-SnCl₄/0.020			Fe₃O₄@SiO₂-SnCl₄/0.020
7	30	85		3	94
8	Fe₃O₄@SiO₂-SnCl₄/0.030			Fe₃O₄@SiO₂-SnCl₄/0.030
8	20	88		2	98
9	Fe₃O₄@SiO₂-SnCl₄/0.040			Fe₃O₄@SiO₂-SnCl₄/0.040
9	20	88		2	98

^a4-Cl-benzaldehyde (1 mmol), 1,3-indanedione (1 mmol), 6-amino-2-(alkylthio)pyrimidin-4(3H)-one (1 mmol) in water (8 mL) at 70 °C
^bIsolated yields

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