Fe3O4@SiO2-SnCl4-promoted synthesis, cytotoxic evaluation, molecular docking, and MD simulation of some indenopyrido[2,3-d]pyrimidine derivatives

Table 1 Optimization of the model reaction condition using various solvents under reflux or ultrasound irradiation^a

Entry	Solvent	T (^oC)	Method I (∆) Time (min)	Yield (%)^a	Method II (US) Time (min)	Yield (%)^b
1	H₂O	r.t	70	60	12	70
2	H₂O	50	60	75	7	85
3	H₂O	60	50	80	5	90
4	H₂O	70	40	85	4	90
5	H₂O	80	40	85	4	90
6	EtOH	70	70	75	7	82
7	MeOH	60	80	60	8	70
8	Acetone	50	70	50	10	60
9	CH₃CN	80	90	40	12	50
10	DMF	120	50	70	6	80
11	HOAc	110	60	70	7	75
12	Solvent-free	120	60	80	6	85

^a4-Cl benzaldehyde (1 mmol), 1,3-indanedione (1 mmol), 6-amino-2-(alkylthio)pyrimidin-4(3H)-one (1 mmol) in water (8 mL) and Fe₃O₄@SiO₂-SnCl₄ (0.01 g)
^bIsolated yields

ISSN: 2661-801X