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Table 3 Assay of Remdesivir and Levodropropizine using the suggested flourimetric approach in single-component dosage forms and co-formulated dosage forms

From: Green synchronous spectrofluorimetric analysis of remdesivir, the first approved antiviral, with levodropropizine as add-on therapy for covid-19: application in their pharmaceutical dosage form, and spiked human plasma

Remdesivir-Eva®

100 mg/vial

Tussistop®

60 mg/tablet

Co-formulated dosage form

Remdesivir

Levodropropizine

Conc.

(ng/mL)

R% *

Conc.

(ng/mL)

R% *

Conc.

(ng/mL)

R %*

Conc.

(ng/mL)

R % *

25

99.38

15

98.27

25

98.94

15

98.12

50

98.71

30

99.01

50

98.62

30

99.20

75

101.95

45

98.12

75

101.84

45

98.34

100

100.69

60

100.39

100

100.56

60

100.47

125

101.27

75

101.46

125

101.37

75

100.86

Mean

100.40

Mean

99.45

Mean

100.27

Mean

99.40

RSD%

1.331

RSD%

1.447

RSD%

1.434

RSD%

1.241

  1. * Average of 3 analyses