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Fig. 4 | BMC Chemistry

Fig. 4

From: Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study

Fig. 4

T. spiralis adult worm incubated in RPMI-1640 medium containing ALN (24.8 μg/ml) for 48 h showing (a): loss of the normal architecture of the cuticle, flattening of the cuticle annulations and widening of the hypodermal glands’ openings (× 1500), (b): blebs formation (× 5000), and (c) appearance of fissures in the cuticle (× 1500). T. spiralis adult worm incubated in RPMI-1640 medium containing ALN (49.6 μg/ml) for 48 h showing (d): complete loss of annulations (× 1500), (e) with sloughing of large areas of the cuticle (× 500), and (f): appearance of multiple vesicles (arrowhead) and a large cauliflower mass (arrow) (× 5000)

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BMC Chemistry

ISSN: 2661-801X

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