BMC Chemistry

Table 3 Determination of CHZ, IBU, PAR, PAP, PNP, and PCA in laboratory-prepared mixtures by the proposed methods

From: Impurity profiling of paracetamol toxic impurities in pharmaceutical combination with ibuprofen and chlorzoxazone using HPLC and TLC densitometric methods

TLC -Densitometric method												HPLC method
Conc (μg/band)						Recovery %^a						Conc (μg/mL)						Recovery %^a
IBU	PAP	PAR	PNP	CHZ	PCA	IBU	PAP	PAR	PNP	CHZ	PCA	PAP	PAR	PNP	IBU	CHZ	PCA	PAP	PAR	PNP	IBU	CHZ	PCA
9.4	1	8	1	9	1	100.81	101.65	99.67	101.37	101.93	104.18	1	8	1	9.4	9	1	101.63	101.12	101.40	100.88	99.36	100.94
8	2	7.2	2	5	2	101.05	102.55	101.43	102.04	98.27	102.26	2	7.2	2	8	5	2	100.44	99.80	99.23	102.80	102.03	98.50
7	4	6.5	4	9	4	101.54	98.29	98.80	99.18	101.40	102.10	4	6.5	4	7	9	4	99.58	101.89	100.32	100.22	99.92	98.02
6.4	6	6	6	6	6	99.57	101.83	98.23	102.10	101.41	100.82	6	6	6	6.4	6	6	101.93	99.80	101.91	102.00	99.98	99.00
20	8	15	8	18	8	101.74	101.41	98.49	101.91	99.81	100.51	8	15	8	20	18	8	101.03	99.00	100.04	98.46	101.69	100.24
Mean R% ± SD						100.94 ± 0.85	101.15 ± 1.65	99.32 ± 1.30	101.32 ± 1.23	100.56 ± 1.51	101.97 ± 1.45	Mean R% ± RSD						100.92 ± 0.94	100.32 ± 1.16	100.58 ± 1.08	100.87 ± 1.68	100.60 ± 1.19	99.34 ± 1.22

^a Average of three determinations

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