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Table 1 Optimize reaction conditions for the production of (5a)

From: Synthesis of thiazoloquinolinone derivatives: molecular docking, MD simulation, and pharmacological evaluation as VEGFR-2 inhibitors

Entry

Solvent

Temp (ºC)

Catalyst (10%)

Time (min)

Yield (%)

1

EtOH

80

Et3N

35

54

2

MeH

65

Piperidine

20

60

3

H2O

80

Piperidine

15

65

4

EtOH/H2O(1:1)

80

Piperidine

20

77

5

CH3CN/H2O(1:1)

80

Et3N

240

94

6

EtOH/ H2O(1:1)

80

Et3N

45

75

  1. Bold indicates optimum conditions
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BMC Chemistry

ISSN: 2661-801X

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