Synthesis and in silico studies of quinoline appended acridine via conventional and green methods: photophysical analysis of novel fluorophore for picric acid detection using a ‘turn-off' fluorescence approach

Table 3 Green Metrics calculation of the synthesized compounds 3a-3d and 4a-4d

Entry	Compound	Molecular formula	Yield (%)	Calculated green chemistry matrices
Entry	Compound	Molecular formula	Yield (%)	AE	PMI	CE	RME	E-factor
1	3a	C₂₅ H₂₅ NO	53.8	90.9	1.297	100	77.1	0.297
2	3b	C₂₅H₂₄ClNO	49.5	90.4	1.295	100	77.2	0.295
3	3c	C₂₅ H₂₃ Cl₂NO	37.7	92.1	1.289	100	77.5	0.289
4	3d	C₂₅ H₂₃ Cl₂NO	50.9	92.0	1.291	100	77.4	0.291
5	4a	C₃₈ H₃₂ N₂	37.6	87.8	1.292	100	77.3	0.292
6	4b	C₃₈H₃₀Cl₂N₂	40.0	87.4	1.289	100	77.5	0.289
7	4c	C₃₈H₂₈Cl₄N₂	23.1	89.8	1.278	100	78.2	0.278
8	4d	C₃₈H₃₀N₄O₄	26.2	89.3	1.282	100	78.0	0.282

AE Atomic economy, PMI Process Mass Intensity, CE Carbon efficiency, RME Reaction mass efficiency

ISSN: 2661-801X