Development of UV-Chemometric techniques for resolving the overlapped spectra of aspirin, caffeine and orphenadrine citrate in their combined pharmaceutical dosage form

Table 4 Pharmaceutical Preparation (Relatic ^® tablets) and standard addition results from using PLS chemometric models

Spectra order		Zero			First derivative			Second derivative			Ratio spectra			Ratio derivative			Ratio 2nd derivative
PLS	Parameter	ASP	CAF	ORP	ASP	CAF	ORP	ASP	CAF	ORP	ASP	CAF	ORP	ASP	CAF	ORP	ASP	CAF	ORP
Pharmaceutical formulation	Mean	100.02	100.03	100.08	100.03	100.01	99.99	100.03	100.12	99.81	103.75	102.42	103.66	103.49	105.40	102.75	103.74	103.42	108.93
Pharmaceutical formulation	SD	0.05	0.14	0.19	0.15	0.04	0.04	0.42	0.42	0.62	6.37	9.15	7.64	9.98	9.21	16.87	22.74	15.66	16.23
Standard addition technique	Mean	100.04	100.03	100.12	100.01	99.99	100.05	99.52	99.85	99.93	102.75	102.33	103.71	107.71	105.77	102.86	108.45	102.91	106.37
Standard addition technique	SD	0.08	0.16	0.12	0.18	0.08	0.07	0.52	0.41	0.75	8.22	8.64	6.20	11.07	13.98	13.45	18.46	15.16	8.94

ISSN: 2661-801X