Table 2 Quantitative determination of EDO in Coaguloban® tablets by the proposed method using direct and standard addition methods
Direct method | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coaguloban® (60 mg Edoxaban per tablet) | Parameters | Micro-CDs | Plate-CD | |||||||||
Conc. taken (µg/mL) | 0.8 | 5 | 20 | 0.8 | 5 | 20 | ||||||
intra-day precision | Mean Recovery %* | 99.67 | 98.10 | 101.55 | 98.38 | 100.11 | 98.77 | |||||
RSD% | 1.21 | 0.97 | 1.04 | 0.95 | 1.07 | 1.13 | ||||||
Inter-day precision | Mean Recovery %* | 97.94 | 100.88 | 99.81 | 97.82 | 101.01 | 97.43 | |||||
RSD% | 1.31 | 1.12 | 2.10 | 1.97 | 1.27 | 0.98 | ||||||
Standard addition method | ||||||||||||
Parameters | Conc. taken (µg/ mL) | Conc. added (µg/mL) | Micro-CDs | Plate CDs | ||||||||
Conc. found (µg/ mL) | %Recovery | Conc. found (µg/ mL) | %Recovery | |||||||||
Coaguloban® (60 mg Edoxaban per tablet) | 5 | 2.5 | 7.61 | 101.47 | 7.65 | 102.00 | ||||||
5 | 9.97 | 99.70 | 9.89 | 98.90 | ||||||||
10 | 14.83 | 98.87 | 15.05 | 100.33 | ||||||||
% Mean Recovery* | 100.01 | 100.41 | ||||||||||
% RSD | 1.33 | 1.55 | ||||||||||