Table 3 Quantitative determination of Letrozole in Femara® tablets by the proposed spectrophotometric methods and application of standard addition technique
Pharmaceutical formulation Femara® (2.5 mg/ tablet) | * Found % ± SD | |||||
|---|---|---|---|---|---|---|
D2 | RD | DD1 | ||||
Batch no. SAWJ9 | 99.84 ± 1.012 | 99.55 ± 0.911 | 99.73 ± 0.752 | |||
Standard addition technique | D2 | RD | DD1 | |||
Added (µg/mL) | Found | Recovery % | Found | Recovery % | Found | Recovery % |
2.00 | 1.99 | 99.50 | 2.03 | 101.5 | 1.99 | 99.5 |
4.00 | 4.02 | 99.25 | 4.03 | 100.75 | 4.13 | 99.75 |
6.00 | 6.04 | 99.83 | 5.98 | 99.67 | 6.16 | 101.67 |
Recovery (Mean % ± SD) | 100.22 ± 0.632 | 100.64 ± 0.920 | 100.31 ± 1.187 | |||