A green three-ratio manipulating spectrophotometric approaches for the determination of a binary mixture of pantoprazole and domperidone

Table 2 Regression and validation data for the determination of pantoprazole and domperidone by the proposed methods

Parameters	RD		¹DD		MC
Parameters	PNT	DOM	PNT	DOM	PNT	DOM
Wavelength (nm)	254–223	208–232	249	215	254	209
Linearity range (μg/mL)	0.5–52	1–18	0.5–52	1–18	0.5–52	1–18
LOD (μg/mL)	0.209	0.621	0.209	0.625	0.209	0.624
LOQ (μg/mL)	0.442	0.912	0.443	0.913	0.439	0.916
Slope (b)	1.0104	0.1706	0.9694	0.0116	1.4331	0.2694
Intercept (a)	− 0.2941	− 0.0032	0.2557	0.0007	− 0.4035	− 0.2742
Coefficient of determination (r²)	0.9998	0.9998	0.9999	0.9998	0.9999	0.9999
Accuracy (%R)^a	100.39	100.17	99.72	99.96	100.23	99.35
Repeatability precision (RSD)^b	1.176	1.141	0.976	0.959	1.509	1.178
Intermediate precision (RSD)^b	1.001	0.919	0.965	0.847	0.79	1.133
Robustness^c (%RSD) Wavelength (± 1 nm)^c	1.251	1.181	1.061	0.972	1.372	1.206

^aNine measurements were averaged (three times in three different concentrations)
^b%RSD of nine measurements (three times in three different concentrations)
^c%RSD of determination of three concentrations of each drug after slight changes in the wavelength (± 1 nm)

ISSN: 2661-801X