Table 1 In vitro antiproliferative activity data of compounds 9–19
From: Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds
Cpd’s designation | aIC50 (µM) | |||
|---|---|---|---|---|
MCF-7 | HT-29 | B16F10 | MEF | |
Paclitaxel (Taxol) | 0.00834 | 0.0166 | 55.7 | 17.23 |
| > 200 | > 200 | > 200 | > 200 |
| > 200 | > 200 | > 200 | 18.5 ± 0.33 |
| 20.47 ± 0.10 | 18.34 ± 1.22 | 39.2 ± 1.84 | 1.84 ± 0.83 |
| 30.88 ± 14.44 | 4.15 ± 2.93 | 64.81 ± 15.78 | 40.54 ± 4.34 |
| 66.48 ± 37.87 | 48.31 ± 0.53 | 197.06 ± 14.42 | 32.93 ± 0.09 |
| 195.26 ± 19.89 | 44.45 ± 0.15 | 21.75 ± 0.81 | > 200 |
| > 200 | > 200 | > 200 | > 200 |
| 84.05 ± 3.37 | 93.08 ± 0.61 | > 200 | > 200 |
| > 200 | > 200 | > 200 | > 200 |
| 14.81 + 0.20 | 10.11 ± 0.70 | 14.39 ± 0.04 | 16.31 ± 0.08 |
| > 200 | 85.50 ± 18.83 | 195.45 ± 15.30 | 63.85 ± 2.33 |
