Nanao/organocatalyat SiO2/4-(2-Aminoethyl)-morpholine as a new, reusable, and efficacious catalyst for the synthesis of polyhydroquinolines derivatives and antibacterially active evaluation

Table 1 Optimization of various reaction conditions

Entry	Catalyst	Catalyst (g)	Temp	Solvent	Time (min)	Yield (%)^b
1	–	–	70	EtOH	50	40
2	SiCl	0.04	70	EtOH	50	45
3	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	70	EtOH	12	95
4	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	70	EtOAc	12	70
5	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	70	H₂O	20	65
6	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	70	EtOH/H₂O (1:1)	12	95
7	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	70	Sovent-free	12	95
8	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	r.t	EtOH/H₂O (1:1)	50	65
9	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.04	50	EtOH/H₂O (1:1)	20	75
11	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.05	70	EtOH/H₂O (1:1)	12	95
12	nano-silica/ 4-(2-Aminoethyl)-morpholine	0.02	70	EtOH/H₂O (1:1)	20	82

Reaction conditions: malononitrile (1 mmol), 4-nitrobenzaldehyde (1 mmol), dimedone (1 mmol), and nano-SiO2/4-(2-Aminoethyl)-morpholine as the catalyst
^bIsolated yield

ISSN: 2661-801X