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Table 6 ∆G (kcal/mol) and binding affinity for each compounds 3 tested with protein

From: New tetrahydroisoquinolines bearing nitrophenyl group targeting HSP90 and RET enzymes: synthesis, characterization and biological evaluation

compound

∆G (kcal/mol)

Standard (Onalespib)

− 7.1

Compound 3

− 6.8