New tetrahydroisoquinolines bearing nitrophenyl group targeting HSP90 and RET enzymes: synthesis, characterization and biological evaluation

Table 2 IC₅₀ of the synthesized compounds against MCF7 and HEPG2 cell lines and their selectivity index

Compd.no	IC₅₀ FOR HSF ± S.D. μg/ml	IC₅₀ for MCF7 ± S.D μg/ml	Selectivity Index = IC₅₀ of HSF/ IC₅₀ of MCF7	IC₅₀ for HEPG2 ± S.D μg/ml	Selectivity Index = IC₅₀ of HSF/IC₅₀ of HEPG2
3	96	33 ± 0.034	2.9	75 ± 0.063	1.2
4	100	47 ± 0.055	2.1	80 ± 0.070	1.2
5	71	33 ± 0.042	2.1	97 ± 0.053	0.73
10	89	> 100	–	> 100	–
2A	100	35 ± 0.061	2.8	82 ± 0.054	1.2
6A	89	21 ± 0.057	4.2	> 100	–
7A	90	50 ± 0.031	1.8	97 ± 0.054	0.92
8A	84	50 ± 0.019	1.6	88 ± 0.072	0.95
8B	100	12 ± 0.056	8.3	94 ± 0.82	1.1
9B	86	80 ± 0.050	1.1	87 ± 0.61	0.98
DOX	83	4.58 ± 0.081	18.1	4.13 ± 0.054	20.1

ISSN: 2661-801X