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Table 5 Analysis of commercial dosage form using the proposed chemometric methods and their statistical comparison with the reported method

From: Ecofriendly and smart spectrophotometric approaches for synchronized analysis of two antipsychotic drugs, fluoxetine and olanzapine: application to combined tablet dosages with assessment of method greenness

Method

% Recovery a ± SD

 

Flunzapine 6/25 mg® capsule

Raibyax 12/25 mg® capsule

 

FLX

OLZ

FLX

OLZ

Reported methods

100.55 ± 1.25

101.47 ± 1.42

100.79 ± 0.84

100.23 ± 0.59

Ratio subtraction

100.34 ± 0.83

(t = 0.31, F = 2.27)b

100.47 ± 0.86

(t = 1.35, F = 2.73)b

100.84 ± 0.76

(t = 0.10, F = 1.22)b

100.35 ± 0.28

(t = 0.41, F = 4.44)b

Dual wavelength

101.74 ± 0.84

(t = 1.77, F = 2.21)b

---

100.43 ± 1.16

(t = 0.56, F = 1.91)b

---

Absorptivity factor

---

99.70 ± 0.91

(t = 2.35, F = 2.43)b

---

101.04 ± 0.84

(t = 1.76, F = 2.03)b

  1. a The value is the average of five measurements for both the proposed and reported methods
  2. b the values in parentheses are t- value and F- value. Tabulated values at 95% confidence limit are t = 2.306 and F = 6.338