Ecofriendly and smart spectrophotometric approaches for synchronized analysis of two antipsychotic drugs, fluoxetine and olanzapine: application to combined tablet dosages with assessment of method greenness

Table 2 Assessment of the accuracy of the proposed chemometric spectrophotometric methods for the determination of FLX and OLZ at four concentration levels

Method	Drug	FLX: OLZ. (µg mL^− 1)	Found ( µg mL^− 1)	% Recovery ^a ± SD	RSD
Ratio Subtract	OLZ	8:4	4.01	100.31 ± 0.375	0.374
		12:6	6.08	101.46 ± 0.30	0.296
		16:8	7.99	99.94 ± 0.451	0.45
		20:10	9.88	98.85 ± 0.543	0.549
	FLX	8:4	8.07	100.85 ± 0.64	0.63
		12:6	12.07	100.59 ± 0.283	0.281
		16:8	15.84	98.97 ± 0.283	0.285
		20:10	19.97	99.83 ± 0.296	0.297
Dual wavelengths	FLX	12:6	12	100.01 ± 0.908	0.907
		16:8	16.07	100.46 ± 0.851	0.847
		20:10	19.99	99.98 ± 1.021	1.021
		24:12	23.94	99.78 ± 0.851	0.853
Absorptivity factor	OLZ	12:6	5.94	99.11 ± 1.26	1.27
		16:8	7.97	99.68 ± 1.15	1.16
		20:10	9.92	99.2 ± 0.335	0.338
		24:12	11.93	99.46 ± 1.191	1.197

^a the value is the average of three determinations, SD is the standard deviation and RSD is the relative standard deviation

ISSN: 2661-801X