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Table 4 Quantification of MOM and OLO in medicinal formulations through the utilization of proposed chemometric analytical approaches, coupled with the implementation of the standard addition methodology

From: Application of machine learning assisted multi-variate UV spectrophotometric models augmented by kennard stone clustering algorithm for quantifying recently approved nasal spray combination of mometasone and olopatadine along with two genotoxic impurities: comprehensive sustainability assessment

Preparation

%Recovery ± %RSD (a)

CLS

PCR

PLS

GA-PLS

MCR-ALS

MOM

Application

100.03 ± 0.862

100.02 ± 0.632

100.02 ± 0.797

100.25 ± 0.527

100.01 ± 0.621

Standard addition

100.23 ± 0.475

100.38 ± 0.673

99.04 ± 0.655

100.85 ± 0.415

99.14 ± 0.622

OLO

Application

100.21 ± 0.824

100.52 ± 0.824

100.11 ± 0.792

100.25 ± 0.651

100.54 ± 0.522

Standard addition

99.98 ± 0.705

99.99 ± 0.646

99.11 ± 0.622

99.74 ± 0.591

100.45 ± 0.692

  1. aAverage of three determinations
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BMC Chemistry

ISSN: 2661-801X

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