Green Chemometric—assisted UV spectrophotometric techniques for the analysis of Helicobacter pylori triple therapy: amoxicillin, metronidazole and famotidine in bulk, individual and laboratory- prepared combined dosage forms: application to simulated gastric fluid with comprehensive greenness and whiteness appraisals

Table 2 Assay results for determination of AMX, MET and FAM by the proposed spectrophotometric methods in their laboratory- prepared combined tablet mixtures in simulated gastric fluid (n = 3)

	Nominal value µg mL⁻¹		Method I D₁/A method				Method II D/DDRS method				Method III FF/A method
	Mix 1	Mix 2	Mean % recovery ± SD^a		RSD (%)^b		Mean% recovery ± SD		RSD (%)		Mean% recovery ± SD		RSD (%)
AMX	40	28					99.24 ± 0.77	100.13 ± 0.50	0.78	0.50	99.26 ± 0.88	100.13 ± 1.04	0.89	1.04
MET	20	16	99.13 ± 0.29	98.70 ± 0.53	0.29	0.54	101.30 ± 1.17	99.70 ± 0.86	1.15	0.86	100.05 ± 1.69	99.27 ± 0.30	1.69	0.30
FAM	3	20	98.93 ± 1.12	100.44 ± 1.20	1.13	1.19	100.20 ± 0.95	101.16 ± 0.34	0.95	0.34	99.87 ± 0.25	99.97 ± 1.18	0.25	1.18

ISSN: 2661-801X