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Table 7 Excretion properties of molecules

From: Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity

 

Desloratadine

Levocetirizine

Fexofenadine

CAPE

Quercetin

Melatonin

Curcumin

Vit C

CLplasma

6.872

1.102

0.785

14.184

8.289

7.852

9.635

4.37

T1/2

0.606

1.464

1.206

1.108

1.586

0.839

1.196

2.056

  1. The unit of predicted CLplasma penetration is ml/min/kg. > 15 ml/min/kg: high clearance; 5–15 ml/min/kg: moderate clearance; < 5 ml/min/kg: low clearance
  2. T ½: The unit of predicted T1/2 is hours. ■ ultra-short half-life drugs: 1/2 < 1 h; short half-life drugs: T1/2 between 1–4 h; intermediate short half-life drugs: T1/2 between 4–8 h; long half-life drugs: T1/2 > 8 h
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BMC Chemistry

ISSN: 2661-801X

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