Table 12 Molecular docking data for Human Histamin H1 Receptor
Compounds | ΔG (kcal/mol) | H bond interaction | Hydrofobic Interaction | Electrostatic interaction |
|---|---|---|---|---|
Desloratadine | − 7.2 | – | VAL71, LEU149, TRP152 |  |
Levocetirizine | − 7.1 | – | TYR158, PRO161, ILE197 | – |
Fexofenadine | − 8.9 | – | PHE116, PHE119, ILE120, ILE123, ALA151, PRO202 | – |
CAPE | − 5.6 | TYR210 | LEU207, ALA211, TYR214 | MET421 |
Quercetin | − 6.6 | GLU181, TYR1850 | TRP93, CYS100, ARG175, CYS180 | ARG97 |
Melatonin | − 6.2 | GLY164, TRP165, ASP183 | VAL187, PHE190 | – |
Curcumin | − 6.1 | TRP152 | LEU149, TRP152, PHE153 | – |
Vitamin C | − 4.8 | GLY164 | – | – |