Table 15 Toxicity parameters of the hydroxytyrosol, oleuropein, apigenin, pinoresinol
Toxicity | Environmental toxicity | Toxicophore rules | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Molecule | hERG | H-HT | AMES Tox | SkinSen - | DILI | Carcinogencity | IGC50 | LC50FM | LC50DM | Acute toxicity rule | Genotoxic carcinogenicity rule |
Hydroxytyrosol | − − | − − | + | + + | − − | – | 3.03 | 3.29 | 4.26 | 0 Alert(s) | 0 Alert(s) |
Oleuropein | − − | – | + + | − − | + + + | + + + | 3.52 | 4.5 | 5.38 | 0 Alert(s) | 1 Alert(s) |
Apigenin | − − | − − | – | + + + | + + | – | 4.58 | 5.20 | 5.20 | 0 Alert(s) | 0 Alert(s) |
Pinoresinol | − − | – | – | + | – | – | 5.02 | 5.80 | 6.63 | 0 Alert(s) | 0 Alert(s) |