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Table 4 Antimicrobial activity screening results of synthesized derivatives and standard drugs

From: Molecular modeling, synthesis and biological evaluation of caffeic acid based Dihydrofolate reductase inhibitors

Compound

MIC (µg/ml)

Bacterial strain

Fungal strain

S. aureus

P. aeruginosa

E. Coli

C. albican

A. niger

CE3

4

2

2

8

32

CE8

16

8

8

32

32

CE11

32

64

64

16

16

CE12

16

64

32

8

16

CE13

8

8

8

64

8

CE15

8

4

4

16

NI

CE17

8

32

8

8

16

CAm7

8

8

4

32

32

Trimethoprim

16

8

8

64

32

Ampicillin

4

8

4

–

–

Tetracycline

–

–

16

–

–

Fluconazole

–

–

–

0.25

-

Voriconazole

–

–

–

–

2

  1. – (Not Tested)
  2. NI (No inhibition)
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BMC Chemistry

ISSN: 2661-801X

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