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Table 9 Analytical Eco-scale for assessing the greenness of the proposed MW-SPA for the quantitation of SEL via formation of a CTC with DDQ

From: Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation

Eco-Scale score parameters

Penalty points (PPs)

Acetonitrile: <1 mL (mL (g) per sample)

1

DDQ: <1 mL (mL (g) per sample)

1

 

∑ = 2

Hazard of solvent/reagent

Solvent: acetonitrile

3

Reagent: DDQ

3

 

∑ = 6

Instrument: Energy used (kWh per sample)

Microplate reader

0

 

∑ = 0

Occupational hazardous

Analytical process hermetic

0

Emission of vapors and gases to the air

0

 

∑ = 0

Waste

Production (<1 mL (g) per sample)

1

Treatment (No treatment involved)

3

 

∑ = 4

Total PPs

12

Eco-Scale score

88