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Table 8 Analysis of SEL in its commercial pharmaceutical capsules by the proposed MW-SPA

From: Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation

Nominal concentration (µg/mL)

SEL bulk form

 

Koselugo® capsule

Found concentration a (µg/mL)

Recovery a (%)

 

Found concentration a (µg/mL)

Label claim a (%)

50

49.2

98.4 ± 1.6

 

50.2

100.4 ± 1.2

100

101.4

101.4 ± 1.8

 

98.8

98.8 ± 1.8

200

198.6

99.3 ± 1.4

 

202.6

101.3 ± 1.4

400

404.5

101.1 ± 1.5

 

396.8

99.2 ± 1.6

 

Mean

100.1

 

Mean

99.9

 

SD

1.4

 

SD

1.1

  1. a Values are mean of three determinations
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BMC Chemistry

ISSN: 2661-801X

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