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Table 7 Greenness evaluation of the proposed and reported chemometrics methods for the determination of ANT and BEN using analytical Eco-scale tools

From: Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness

Proposed method

Reported method [17]

Reported method [45]

Analytical eco-scale

Penalty point

Analytical eco-scale

Penalty point

Analytical eco-scale

Penalty point

Reagents

Reagents

Reagents

Distilled water

0

Ethanol

4

0.01 N HCl

4

  

0.1 N HCl

4

  

Instrument

Instrument

Instrument

Energy (< 1.5 kWh per sample)

1

Energy (< 1.5 kWh per sample)

1

Energy (< 1.5 kWh per sample)

1

Occupational hazard

0

Occupational hazard

0

Occupational hazard

0

Waste

3

Waste

3

Waste

3

Total penalty points

4

Total penalty points

12

Total penalty points

8

Eco-scale score

96

Eco-scale score

88

Eco-scale score

92