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Fig. 5 | BMC Chemistry

Fig. 5

From: Development of an HPLC–UV method for quantification of posaconazole in low-volume plasma samples: design of experiments and machine learning models

Fig. 5

a Pareto chart and three-dimensional surface response plots of b volume of extraction solvent and plasma pH, c volume of extraction solvent and NaCl, d volume of extraction solvent and extraction time, e volume of extraction solvent and centrifuge time, f plasma pH and NaCl, g NaCl and extraction time, and (h) extraction and centrifuge time on PCZ recovery. i Pareto chart and three-dimensional surface response plots of j volume of extraction solvent and NaCl, k volume of extraction solvent and centrifuge time, l NaCl and extraction time, and m extraction and centrifuge time on IS recovery A: volume of extraction solvent; B: plasma pH; C: NaCl; D: extraction time; E: centrifuge time; IS internal standard, PCZ posaconazole

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BMC Chemistry

ISSN: 2661-801X

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