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Fig. 1 | BMC Chemistry

Fig. 1

From: Molecular exploration of natural and synthetic compounds databases for promising hypoxia inducible factor (HIF) Prolyl-4- hydroxylase domain (PHD) inhibitors using molecular simulation and free energy calculations

Fig. 1

A Structure of Vadadustat B Structure of Roxadustat C The catalytic domain of PHD2 complexed with Vadadustat (AKB-6548) and showing Bidentate coordination of iron (orange sphere) and hydrogen bonding with Arg383, Tyr329 and Tyr303. D The catalytic domain of PHD2 complexed with Roxadustat (FG4529) and showing Bidentate coordination of iron (orange sphere) and hydrogen bonding with Arg383, Tyr329, and Tyr303

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BMC Chemistry

ISSN: 2661-801X

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