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Table 3 In vitro MIC, MFC (µg/mL), and MFC/MIC ratio of the tested molecules

From: New N-amino-5-cyano-6-pyridones as antimicrobial small molecules endowed with DNA gyrase a inhibitory activity: design, one-pot synthesis, biological assessment and in silico insights

Compound

S. cerevisiae

 

C. albicans

 

MIC

MFC

MFC/ MIC ratio

MIC

MFC

MFC/ MIC ratio

3a

31.3

125

4

125

500

4

3b

125

250

2

62.5

125

2

3c

31.3

125

4

62.5

125

2

3d

31.3

62.5

2

125

500

4

3e

62.5

125

2

62.5

125

2

4a

62.5

500

8

31.3

62.5

2

4b

125

500

4

31.3

62.5

2

4c

62.5

125

2

15.6

62.5

4

4d

31.3

62.5

2

62.5

125

2

Ketoconazole

1.95

15.6

 

1.95

31.3

 
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BMC Chemistry

ISSN: 2661-801X

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