Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile

Table 1 Varied Substitution of pyrrole derived triazole based Schiff base (1–16) and their biological profile

S/No	Acetylcholinesterase (AchE) IC₅₀ = (µM) ± SEM	Butyrylcholinesterase (BChE) IC₅₀ = (µM) ± SEM
1	8.20 ± 0.20	9.10 ± 0.50
2	14.20 ± 0.10	15.10 ± 0.10
3	15.10 ± 0.60	16.40 ± 0.20
4	13.20 ± 0.20	14.10 ± 0.20
5	19.30 ± 0.20	21.10 ± 0.10
6	6.20 ± 0.10	6.80 ± 0.20
7	5.10 ± 0.40	5.60 ± 0.30
8	13.60 ± 0.20	14.30 ± 0.10
9	8.80 ± 0.10	9.60 ± 0.10
10	22.90 ± 0.10	23.10 ± 0.20
11	7.10 ± 0.20	7.80 ± 0.30
12	9.20 ± 0.20	9.70 ± 0.20
13	15.50 ± 0.20	16.10 ± 0.20
14	25.10 ± 0.40	26.20 ± 0.40
15	27.10 ± 0.10	28.40 ± 0.30
16	21.20 ± 0.10	22.20 ± 0.10
Standard drug Donepezil Allanzanthone	10.20 ± 0.10\ 12.40 ± 0.10	10.80 ± 0.20 13.10 ± 0.10

ISSN: 2661-801X