Extraction of methamphetamine and pseudoephedrine by modified graphene oxide solid phase extraction method coupled to HPLC-UV in urine sample

Table 4 Comparison of the proposed methods with other techniques for analysis of Met and PS in urine

Method	Analyte	Concentration range (µg/L)	LOD/LLOQ (µg/L)
EM-SPME³-GC-FID [45]	Methamphetamine	5-500	2.0
MIP-SPME⁴-CE [46]	Pseudoephedrine	5-500	1.1
DLLME-SFOP¹-HPLC-UV [48]	Methamphetamine	10-3000	2
Head-space-SPME²-GC-MS [49]	Methamphetamine	0.5–1000	0.2
DSPE-HPLC-UV (this study)	Methamphetamine	250-12000	250
MSPE⁵-HPLC-UV (this study)	Methamphetamine and Pseudoephedrine	1000–15,000	1000

¹Electromembrane solid-phase microextraction-GC-FID
²Molecularly imprinted polymer- solid-phase microextraction-CE
³Dispersive liquid–liquid microextraction - solidification of floating organic drop-HPLC-UV
⁴Headspace solid-phase microextraction- GC-MS
⁵Magnetic solid-phase extraction-HPLC-UV

ISSN: 2661-801X