Table 7 Results of accelerated stability studies for 6 months (temp. 40 °C ± 2 °C and RH 75% ± 5%)
Physical parameter | Initial | 1 month | 3 month | 6 month |
|---|---|---|---|---|
Appearance | White colored, oval tablet | White colored, oval tablet | White colored, oval tablet | White colored, oval tablet |
Average weight (mg) | 970 ± 3.30 | 975 ± 2.30 | 978 ± 2.10 | 980 ± 2.40 |
Friability (%) | 0.52 ± 0.02 | 0.55 ± 0.01 | 0.59 ± 0.06 | 0.62 ± 0.11 |
Hardness (kg/cm2) | 7.1 ± 0.30 | 7.3 ± 0.50 | 7.5 ± 0.70 | 7.9 ± 0.95 |
Thickness (mm) | 9.3 ± 1.80 | 9.3 ± 1.80 | 9.3 ± 1.90 | 9.3 ± 2.30 |
Drug content (%) | 97.24 ± 1.80 | 97.00 ± 2.30 | 96.98 ± 2.90 | 96.85 ± 2.90 |
Drug release after 20 h (%) | 91.00 ± 0.764 | 90.9 ± 2.58 | 90.5 ± 3.10 | 89.46 ± 1.10 |