Greenness and whiteness appraisal for bioanalysis of quetiapine, levodopa and carbidopa in spiked human plasma by high performance thin layer chromatography

Table 5 Results of stability of QUET, LD and CD in spiked human plasma

Drug	Concentration (ng/mL)		Benchtop stability			Freeze and thaw stability
Drug	Concentration (ng/mL)		Recovery (%)^a	% RSD^a	% Dev^b	Recovery (%)^a	% RSD^a	% Dev^b
QUET	QCL	300.0	98.76	0.45	− 1.97	96.68	0.91	− 4.03
QUET	QCH	3200.0	97.44	0.08	− 3.04	99.46	1.63	− 1.04
LD	QCL	600.0	99.13	0.70	− 1.11	98.34	1.44	− 1.90
LD	QCH	6000.0	97.91	1.57	− 2.00	102.23	7.00	2.29
CD	QCL	60.0	97.05	5.28	− 1.47	94.90	3.48	− 3.68
CD	QCH	1000.0	96.80	2.44	− 2.69	96.37	1.66	− 3.13

^a n = 3
^b % Dev = [(% R of old QC sample—% R of fresh QC sample) / % R of fresh QC sample] × 100

ISSN: 2661-801X