Table 8 The projected ADMET characteristics for the identified hits
Name | Bioavailability score | GI absorption | log Kp (cm/s) | logS | Mutagenic | Tumorigenic | Reproductive effective | Irritant |
|---|---|---|---|---|---|---|---|---|
M1 | 0.55 | High | − 7.84 | − 4.12 | None | None | None | None |
M2 | 0.55 | Low | − 7.03 | − 5.87 | None | None | None | None |
M3 | 0.55 | High | − 7.29 | − 3.8 | None | None | None | None |
M4 | 0.55 | High | − 6.92 | − 4.89 | None | None | Low | None |
N1 | 0.55 | High | − 6.37 | − 4.7 | None | None | None | None |
N2 | 0.55 | High | − 7.37 | − 4.02 | None | None | None | None |
N3 | 0.55 | High | − 7.94 | − 3.48 | None | None | None | None |
N4 | 0.56 | High | − 6.7 | − 4.39 | None | None | None | None |
N5 | 0.55 | High | − 7.01 | − 4.1 | None | High | High | None |
N6 | 0.55 | High | − 6.9 | − 4.38 | None | None | None | None |
N7 | 0.55 | High | − 6.06 | − 5.6 | None | None | None | None |
N8 | 0.56 | High | − 7.07 | − 3.55 | None | High | High | None |
N9 | 0.56 | High | − 6.54 | − 4.46 | None | None | None | None |
N10 | 0.55 | High | − 6.62 | − 4.87 | None | None | None | None |
N11 | 0.55 | High | − 6.48 | − 4.83 | None | None | None | None |