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Table 5 MRS model constants at the investigated temperatures and MRD% for back-calculated NAP solubility in two investigated binary mixtures of (1-PrOH + EG) and (2-PrOH + EG)

From: Solubility determination, mathematical modeling, and thermodynamic analysis of naproxen in binary solvent mixtures of (1-propanol/2-propanol) and ethylene glycol at different temperatures

Binary system

T (K)

β1

β2

β3

β4

β5

MRD%

1-PrOH + EG

293.2

-4.376

-6.137

0.008

0.004

3.170

2.6

298.2

-4.289

-6.066

0.008

0.004

3.184

2.7

303.2

-4.164

-5.945

0.008

0.004

3.197

2.6

3.8.2

-3.872

-5.753

0.007

0a

2.650

3.8

313.2

-3.894

-5.585

0.007

0.004

2.802

2.9

Overall MRD%

    

2.9

2-PrOH + EG

293.2

-4.637

-5.716

0a

-0.002

2.366

0.7

 

298.2

-4.584

-5.643

0a

0a

2.445

0.8

 

303.2

-4.441

-5.516

0a

-0.0008

2.422

0.7

 

3.8.2

-4.181

-5.381

0a

0a

2.316

0.9

 

313.2

-3.971

-5.149

0a

0.001

2.198

0.8

 

Overall MRD%

    

0.8

  1. a Not statistically significant (p-value > 0.05)