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Table 2 Experimental mole fraction solubility (\(\:{\chi}_{m,T}\)± SD) for NAP in different binary mixtures at 298.15 K

From: Solubility determination, mathematical modeling, and thermodynamic analysis of naproxen in binary solvent mixtures of (1-propanol/2-propanol) and ethylene glycol at different temperatures

w1a

2-PrOH + EG

[this work]

1-PrOH + EG

[this work]

EG + Water

[7]

Ethyl acetate + EtOH

[12]

PEG 200 + Water

[13]

EtOH + PG

[11]

0.00

3.82 (± 0.04) × 10–3

3.82 (± 0.04) × 10–3

6.57 (± 0.34) × 10–6

1.480 (± 0.006)

5.12 × 10–6

NR

0.10

5.09 (± 0.08) × 10–3

4.24 (± 0.09) × 10–3

7.30 (± 0.23) × 10–6

1.987 (± 0.002)

1.36 × 10–5

NRb

0.20

6.74 (± 0.23) × 10–3

5.97 (± 0.18) × 10–3

9.34 (± 0.01) × 10–6

2.49 (± 0.03)

3.85 × 10–5

9.86 (± 0.03) × 10–3

0.30

8.20 (± 0.21) × 10–3

7.86 (± 0.24) × 10–3

1.53 (± 0.01) × 10–5

3.17 (± 0.03)

1.93 × 10–4

NR

0.40

9.90 (± 0.36) × 10–3

1.13 (± 0.03) × 10–2

2.74 (± 0.15) × 10–5

3.743 (± 0.007)

3.85 × 10–4

1.26 (± 0.01) × 10–2

0.50

1.10 (± 0.02) × 10–2

1.34 (± 0.01) × 10–2

5.62 (± 0.17) × 10–5

4.349 (± 0.014)

8.43 × 10–4

NR

0.60

1.20 (± 0.02) × 10–2

1.43 (± 0.01) × 10–2

1.21 (± 0.00) × 10–4

4.802 (± 0.007)

2.31 × 10–3

1.41 (± 0.01) × 10–2

0.70

1.23 (± 0.02) × 10–2

1.52 (± 0.01) × 10–2

2.98 (± 0.05) × 10–4

5.046 (± 0.024)

3.81 × 10–3

NR

0.80

1.24 (± 0.01) × 10–2

1.63 (± 0.01) × 10–2

7.81 (± 0.21) × 10–4

4.897 (± 0.023)

7.77 × 10–3

1.49 (± 0.01) × 10–2

0.90

1.17 (± 0.01) × 10–2

1.68 (± 0.01) × 10–2

1.83 (± 0.07) × 10–3

4.149 (± 0.005)

1.23 × 10–2

NR

1.00

1.04 (± 0.03) × 10–2

1.75 (± 0.02) × 10–2

3.98 (± 0.01) × 10–3

2.571 (± 0.017)

1.95 × 10–2

NR

  1. aw1 is the mass fraction of 2-PrOH/1-PrOH/EG/ethyl acetate/ PEG 200/ EtOH in the reported binary mixtures in the absence of NAP, respectively
  2. b Not reported