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Table 6 Kinetic parameters of amyloid aggregation formation from apo/holo SOD1 and mutants in 50 mM Tris, 0.2 M KSCN, and 50 mM DTT at pH 7.4 with agitation at 190 rpm at 37 °C

From: Mutation/metal deficiency in the "electrostatic loop" enhanced aggregation process in apo/holo SOD1 variants: implications for ALS diseases

 

Lag time (h)

Kapp(h−1)

holo-WT

77 ± 5

0.08 ± 0.02

holo-L126S

51 ± 8

0.25 ± 0.06

apo-WT

46 ± 6

0.14 ± 0.04

apo-L126S

24 ± 4

0.18 ± 0.08

  1. Data were expressed as mean ± SD (n = 2)
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BMC Chemistry

ISSN: 2661-801X

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