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Table 5 Calculated thermodynamic stability parameters for the apo/holo SOD1 variants protein, against GdnHCl, in the presence of DTT

From: Mutation/metal deficiency in the "electrostatic loop" enhanced aggregation process in apo/holo SOD1 variants: implications for ALS diseases

Protein

ΔG0 H2O N → D (kJ.mol−1)

m (kJ.M−1.mol−1)

holo-WT

13 ± 0.33

4.51 ± 0.38

holo-L126S

7 ± 0.65

1.68 ± 0.21

apo-WT

9.4 ± 0.25

2.064 ± 0.29

apo-L126S

5.2 ± 0.36

1.67 ± 0.12

  1. Data were expressed as mean ± SD (n = 2)
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BMC Chemistry

ISSN: 2661-801X

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