Skip to main content

Table 5 Inhibitory activities of the oxindole–benzothiazole conjugate 9o on different kinases

From: Oxindole–benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation

Compound ID

(IC50 in µM)a

CDK1

CDK5

VEGFR-2

FGFR-1

9o

1.19 ± 0.10

0.34 ± 0.02

> 10

> 10

Staurosporine

0.002 ± 0.0001

0.001 ± 0.0001

ndb

ndb

Sorafenib

ndb

ndb

0.10 ± 0.01

0.58 ± 0.10

  1. aResults are mean of two independent experiments ± standard deviation (SD)
  2. bNot detected
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us