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Table 4 Inhibitory activity of the oxindole–benzothiazole conjugates 9b, 9f and 9o on CDK2

From: Oxindole–benzothiazole hybrids as CDK2 inhibitors and anticancer agents: design, synthesis and biological evaluation

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Compound ID

R1

CDK2 (IC50 in µM)a

9b

Me

0.70 ± 0.013

9f

Br

0.20 ± 0.035

9o

–

0.21 ± 0.015

Staurosporine

–

0.022 ± 0.002

  1. aResults are mean of two independent experiments ± standard deviation (SD)
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BMC Chemistry

ISSN: 2661-801X

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