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Table 5 Synthesis of Pyrrole derivations with Humin-SO3H

From: Humin-sulfuric acid as a novel recoverable biocatalyst for pyrrole synthesis in water

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Entry

Amine

Product

Time (h)

Yield (%)

TON

TOF (h−1)

1

1

98

26.48

26.48

2

1.5

98

26.48

17.65

3

1.5

98

26.48

17.65

4

1.5

97

26.21

17.48

5

2.5

97

26.21

10.48

6

3

88

23.78

7.92

7

5

85

22.97

4.59

  1. Reaction conditions: 2,5-Dimethoxy tetrahydrofuran (1.2 mmol), amine (1 mmol), water (4 mL), and Humin-SO3H (0.01 g) were stirred at 80 ℃