Synthesis and PASS-assisted evaluation of new heterocyclic compounds containing hydroquinoline scaffolds

BMC Chemistry

Table 2 PASS-predicted activity of the test compounds

Compound	Probability of a Compound Being Active (Pa) or Inactive (Pi)
	Antiallergic		Antiasthmatic		Antiarthritic		Progesterone Antagonist		Gluconate 2-Dehydrogenase (Acceptor) Inhibitor
	Pa	Pi	Pa	Pi	Pa	Pi	Pa	Pi	Pa	Pi
7	0.546	0.025	0.471	0.032	0.422	0.071	0.827	0.001	-	-
8	0.691	0.009	0.63	0.013	0.626	0.025	0.276	0.003	-	-
9a	-	-	-	-	-	-	0.367	0.003	-	-
9b	0.509	0.027	0.385	0.053	0.455	0.06	0.18	0.004	-	-
10a	-	-	-	-	-	-	0.266	0.003	-	-
10b	0.287	0.101	-	-	0.311	0.126	0.212	0.007	-	-
12a	-	-	-	-	-	-	0.142	0.005	-	-
12b	0.571	0.018	0.533	0.023	0.616	0.026	0.06	0.017	-	-
13a	0.311	0.088	0.257	0.117	0.488	0.051	0.515	0.002	0.87	0.005
13b	0.707	0.008	0.694	0.009	0.771	0.01	0.217	0.004	0.869	0.005
14	0.543	0.022	0.462	0.033	0.641	0.023	0.145	0.005	0.849	0.008
16	0.556	0.02	0.42	0.042	0.379	0.088	0.506	0.002	0.441	0.254
17	0.423	0.046	0.267	0.11	0.29	0.139	0.71	0.002	-	-
19a	0.305	0.09	-	-	0.248	0.172	0.63	0.002	-	-
19b	0.247	0.134	-	-	-	-	0.394	0.003	-	-
19c	0.392	0.055	0.231	0.139	-	-	0.615	0.002	-	-
19d	0.227	0.109	-	-	-	-	0.429	0.003	-	-
21	0.28	0.106	-	-	0.21	0.205	0.493	0.002	-	-
22	-	-	-	-	0.372	0.091	0.305	0.003	-	-

ISSN: 2661-801X