BMC Chemistry

Table 3 Electrochemical synthesis of bisindolylmethane derivatives 3a–n using the optimum reaction conditions

From: Green electrosynthesis of bis(indolyl)methane derivatives in deep eutectic solvents


Entry	Cpd	Ar	Yield (%)	MP (^oC)	References
1	3a	C₆H₅	71	116–118	[73]
2	3b	4-ClC₆H₄	92	107–108	[74]
3	3c	4-BrC₆H₄	100	108–110	[75]
4	3d	4-FC₆H₄	92	130–132	[76]
5	3e	3-OHC₆H₄	60	130–132	[77]
6	3f	4-OHC₆H₄	93	125–127	[78]
7	3g	4-CH₃C₆H₄	83	138–140	[79]
8	3h	4-CH₃OC₆H₄	92	130–132	[79]
9	3i	3,4-(CH₃O)₂C₆H₃	94	140–142	[80]
10	3j	3,4,5-(CH₃O)₃C₆H₂	95	141–143	[81]
11	3k	4-OH-3-CH₃OC₆H₃	100	121–123	[82]
12	3l	2-NO₂C₆H₄	86	125–127	[80]
13	3m	4-NO₂C₆H₄	89	190–192	[83]
14	3n	3-indolyl	82	198–200	[84]

Reaction conditions: 1 (2 mmol), 2a–n (1 mmol), in ethylene glycol/choline chloride (2:1; 10 mL) for 45 min. at 80 °C and c.c 30 mA. Graphite and platinum were used as cathode and anode, respectively

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