Table 4 Predicted physicochemical properties of compounds 1–10 using the SwissADME server
Compound | Molecular weight (< 500) | TPSAa (< 140A˚2) | H-Bond Acceptor (< 10) | H-Bond Donnor (< 5) | LogP (< 5) | Lipinski’sViolation |
|---|---|---|---|---|---|---|
1 | 373.41 | 81.41 | 5 | 1 | 3.32 | 0 |
2 | 452.3 | 81.41 | 5 | 1 | 3.93 | 0 |
3 | 407.85 | 81.41 | 5 | 1 | 3.85 | 0 |
4 | 351.4 | 72.62 | 5 | 0 | 2.93 | 0 |
5 | 385.85 | 72.62 | 5 | 0 | 3.39 | 0 |
6 | 387.43 | 81.41 | 5 | 1 | 3.58 | 0 |
7 | 416.27 | 72.62 | 5 | 0 | 3.28 | 0 |
8 | 434.49 | 84.21 | 4 | 2 | 3.88 | 0 |
9 | 462.55 | 84.21 | 4 | 2 | 4.34 | 0 |
10 | 496.99 | 84.21 | 4 | 2 | 4.88 | 1 |