Fig. 4

Docking results of test compounds against methyl transferase. a docking pose of compound 1 (dark blue) overlapped with co-crystalized ligand (green). b docking pose of compound 5 (pink). c validation of docking procedure showing docked (blue) pose overlapped with co-crystalized pose (green). d interactions of co-crystalized ligand in the active site methyl transferase. e structure of S-adenosylmethionine (SAM)