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Table 4 ANOVA fit statistics of proposed method

From: QbD green analytical procedure for the quantification of tolvaptan by utilizing stability indicating UHPLC method

 

Retention time

Tailing factor

Theoretical plates

Std. Dev

0.0158

0.0430

35.97

Mean

1.62

1.20

2215.95

C.V. %

0.9788

3.59

1.62

R2

0.9712

0.8456

0.7848

Adjusted R2

0.9452

0.7067

0.5911

Predicted R2

0.7561

0.0946

− 0.2803

Adeq. precision

20.1901

8.4016

6.8243

Lack of fit (p-values)

0.0713

0.4154

0.2872