Effect of 2-hydroxyethylammonium carboxylate protic ionic liquids on the solubility and cytotoxicity of indomethacin

Table 9 The apparent thermodynamic functions for the dissolution process at mean temperature for the IMC in aqueous PILs as a function of the PILs weight fractions (w₃)

w₃	\(\Delta H_{so\ln }^{^\circ }\)/Kj mol⁻¹	\(T_{M} \Delta S_{so\ln }^{^\circ }\)/kJ mol⁻¹	\(\Delta G_{so\ln }^{^\circ }\)/kJ mol⁻¹	\(\xi_{H}\)	\(\xi_{TS}\)
Indomethacin (1) + (2-hydroxyethylammonium propionate) (2) + water (3)
0.0000	25.32	− 9.26	34.58	73.23	26.77
0.0200	32.28	3.14	29.14	91.14	8.86
0.0500	36.19	7.99	28.20	81.92	18.08
0.0700	58.98	31.30	27.68	65.33	34.67
0.1000	76.75	49.74	27.01	60.68	39.32
0.1500	83.99	58.61	25.38	58.90	41.10
0.2000	62.63	38.42	24.21	61.98	38.02
Indomethacin (1) + (2-hydroxyethylammonium acetate) (2) + water (3)
0.0000	25.32	− 9.26	34.58	73.23	26.77
0.0200	18.18	− 10.29	28.47	63.86	36.14
0.0500	15.32	− 12.59	27.91	54.90	45.10
0.0700	8.90	− 18.73	27.63	32.21	67.79
0.1000	10.67	− 16.78	27.45	38.86	61.14
0.1500	19.13	− 7.75	26.87	71.17	28.83
0.2000	10.61	− 15.56	26.17	40.54	59.46
Indomethacin (1) + (2-hydroxyethylammonium lactate) (2) + water (3)
0.0000	25.32	− 9.26	34.58	73.23	26.77
0.0200	22.10	− 3.12	25.22	87.61	12.39
0.0500	26.54	2.50	24.04	91.39	8.61
0.0700	33.85	10.28	23.57	76.70	23.30
0.1000	26.70	3.81	22.89	87.50	12.50
0.1500	30.15	8.36	21.79	78.28	21.72
0.2000	23.65	2.57	21.07	90.18	9.82

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